{"id":5048,"date":"2022-02-02T21:22:39","date_gmt":"2022-02-02T21:22:39","guid":{"rendered":"https:\/\/wordpress-362763-2338092.cloudwaysapps.com\/?page_id=5048"},"modified":"2022-07-21T19:45:45","modified_gmt":"2022-07-21T19:45:45","slug":"schaefer-research-center","status":"publish","type":"page","link":"https:\/\/schaefer.com.br\/schaefer-research-center\/","title":{"rendered":"Schaefer Research Center"},"content":{"rendered":"\t\t
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Assessment of the corneal endothelium in patients undergoing temporary myopia therapy (Ortho-K) with CRT lenses.<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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AuthorBlock:\u00a0<\/b>Tania Schaefer<\/i>1<\/i>, Bruce Koffler<\/i>2<\/i>, Fernando Cesar Abib<\/i>3,4<\/i>
1Ophthalmology, Clinica Schaefer, Curitiba, Parana, Brazil; 2Koffler Vision Group , Lexington, Kentucky, United States; 3Anatomy, Federal University of Paran\u00e1, Curitiba, Brazil; 4Ophthamology, Erasto Gaertner Hospital, Curitiba, Brazil;
DisclosureBlock:\u00a0<\/b>Tania Schaefer, None; Bruce Koffler, None; Fernando Cesar Abib, None.<\/p>

  • Orthokeratology is a form of temporary corneal refractive therapy involving the overnight use of contact lenses.<\/li>
  • During sleep, eyelid occlusion and contact lenses act as barriers to oxygen flow for corneal metabolism and may induce adverse effects and complications such as Corneal Oxygen Deficiency (COD), causing morphological alterations in the endothelium cells.<\/li>
  • Specular microscopy (SM) has been the main technique to evaluate the corneal endothelium. Recently, reliability indexes have been suggested for SM procedures that decrease in 75% the differences between serial SMs.<\/li>
  • No studies have assessed the endothelial mosaic according to the suggested reliability indexes for patients undergoing Orthokeratology.<\/li><\/ul>

    Purpose<\/strong><\/h2>
    • The purpose of the study is to evaluate the endothelial mosaic of Paragon CRT\u00ae 100 wearers whose sampling error of 5% or less is accepted.<\/li><\/ul>

      Methods<\/b><\/h2>
      • Clinical trial performed at Cl\u00ednica Schaefer Research Center, Brazil, Authorization 1.766.502 CONEP, in myopic patients, age 18-27, between -0.75 and -6.00D, with or without astigmatism up to<\/li>
      • -1.75D.<\/li>
      • Patients with diseases that restrict the fitting of CL were excluded
        from the study.<\/li>
      • Ortho-K lenses used include Paragon CRT\u00ae and Paragon CRT\u00ae 100, paflufocon B and D. Nidek specular microscope (Gamagori, Japan) was used to calculate the endothelial cell density (ECD), cellular area (CA), coefficient of variation (CV), and percentage of hexagonal cells (%H).<\/li>
      • The Reliability Index was calculated by the Cells AnalyzerUSA Patent<\/i><\/b>\u00a0(CA)(Technicall, Brazil), and provided sample accuracy of 95% Reliability Degree and 0.05 Relative Error (RE). Sampling included cells from 3 different endothelial images of the corneal central area, considered representative of the endothelial mosaic: RE<5%.<\/li>
      • To compare the studied times (T0 control, T1-T3 (monthly) and T4 (5th month)), Student\u2019s t-test was used for paired samples. Values of p<0.05 showed statistical significance. Statistical analysis was conducted with IBM SPSS Statistics v.20.0. Armonk, NY.<\/li><\/ul>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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        Assessment of the corneal endothelium in patients undergoing temporary myopia therapy (Ortho-K) with CRT lenses. AuthorBlock:\u00a0Tania Schaefer1, Bruce Koffler2, Fernando Cesar Abib3,41Ophthalmology, Clinica Schaefer, Curitiba, Parana, Brazil; 2Koffler Vision Group , Lexington, Kentucky, United States; 3Anatomy, Federal University of Paran\u00e1, Curitiba, Brazil; 4Ophthamology, Erasto Gaertner Hospital, Curitiba, Brazil;DisclosureBlock:\u00a0Tania Schaefer, None; Bruce Koffler, None; Fernando Cesar […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-5048","page","type-page","status-publish","hentry"],"yoast_head":"\nSchaefer Research Center - Cl\u00ednica Schaefer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/schaefer.com.br\/schaefer-research-center\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Schaefer Research Center - Cl\u00ednica Schaefer\" \/>\n<meta property=\"og:description\" content=\"Assessment of the corneal endothelium in patients undergoing temporary myopia therapy (Ortho-K) with CRT lenses. AuthorBlock:\u00a0Tania Schaefer1, Bruce Koffler2, Fernando Cesar Abib3,41Ophthalmology, Clinica Schaefer, Curitiba, Parana, Brazil; 2Koffler Vision Group , Lexington, Kentucky, United States; 3Anatomy, Federal University of Paran\u00e1, Curitiba, Brazil; 4Ophthamology, Erasto Gaertner Hospital, Curitiba, Brazil;DisclosureBlock:\u00a0Tania Schaefer, None; Bruce Koffler, None; Fernando Cesar […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/schaefer.com.br\/schaefer-research-center\/\" \/>\n<meta property=\"og:site_name\" content=\"Cl\u00ednica Schaefer\" \/>\n<meta property=\"article:modified_time\" content=\"2022-07-21T19:45:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/schaefer.com.br\/wp-content\/uploads\/2022\/03\/table-corneal-endothelium.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. tempo de leitura\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/schaefer.com.br\/schaefer-research-center\/\",\"url\":\"https:\/\/schaefer.com.br\/schaefer-research-center\/\",\"name\":\"Schaefer Research Center - Cl\u00ednica Schaefer\",\"isPartOf\":{\"@id\":\"https:\/\/schaefer.com.br\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/schaefer.com.br\/schaefer-research-center\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/schaefer.com.br\/schaefer-research-center\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/schaefer.com.br\/wp-content\/uploads\/2022\/03\/table-corneal-endothelium.jpg\",\"datePublished\":\"2022-02-02T21:22:39+00:00\",\"dateModified\":\"2022-07-21T19:45:45+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/schaefer.com.br\/schaefer-research-center\/#breadcrumb\"},\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/schaefer.com.br\/schaefer-research-center\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"pt-BR\",\"@id\":\"https:\/\/schaefer.com.br\/schaefer-research-center\/#primaryimage\",\"url\":\"https:\/\/schaefer.com.br\/wp-content\/uploads\/2022\/03\/table-corneal-endothelium.jpg\",\"contentUrl\":\"https:\/\/schaefer.com.br\/wp-content\/uploads\/2022\/03\/table-corneal-endothelium.jpg\",\"width\":850,\"height\":308},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/schaefer.com.br\/schaefer-research-center\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"In\u00edcio\",\"item\":\"https:\/\/schaefer.com.br\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Schaefer Research Center\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/schaefer.com.br\/#website\",\"url\":\"https:\/\/schaefer.com.br\/\",\"name\":\"Cl\u00ednica Schaefer\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/schaefer.com.br\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"pt-BR\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Schaefer Research Center - Cl\u00ednica Schaefer","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/schaefer.com.br\/schaefer-research-center\/","og_locale":"pt_BR","og_type":"article","og_title":"Schaefer Research Center - Cl\u00ednica Schaefer","og_description":"Assessment of the corneal endothelium in patients undergoing temporary myopia therapy (Ortho-K) with CRT lenses. 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